2008年获山东大学博士学位； 2009年5月至2011年9月，中国科学院微生物研究所博士后流动站； 2011年9月到中国农业科学院生物技术研究所工作
人才团队
刘 波研究员，博士生导师
博士后
研究员
博士生导师
liubo01@caas.cn
研究中心
农业微生物学
创新团队
微生物蛋白设计与智造
课 题 组
张伟课题组
招生方向
生物化学与分子生物学
学习工作经历
主要研究领域与成果
1、毕赤酵母代谢调控机制 2、微生物高效表达系统挖掘及应用 曾主持一项国家自然科学基金项目（冷休克蛋白调控腾冲嗜热厌氧杆菌冷应激反应的机制《32100072》）、参加十二五863 课题（基因组多位点快速进化与改良《2012AA022105》）和国家自然科学基金项目《链霉菌次级代谢产物生物合成中重要调控基因作用的分子机制》。主持国家自然基金面上项目（食品级毕赤酵母鼠李糖诱导系统高效表达机制的研究《31671802》）（2016-2020）
Chengliang Yan, Xinxin Xu, Xue Zhang, Yuwei Zhang, uhong Zhang, Zhifang Zhang,
Wei Zhang* and Bo Liu*. Decreased rhamnose metabolic flux improved production of target proteins and cell flocculation in Pichia pastoris. Front. Microbiol. 2018, 9: 1771. doi: 10.3389/fmicb.2018.01771.
Bo Liu, Yuwei Zhang, Xue Zhang, Chengliang Yan, Yuhong Zhang, Xinxin Xu, Wei Zhang. Discovery of a rhamnose utilization pathway and rhamnose-inducible promoters in Pichia pastoris. Scientific Reports, 2016, 6:27352. 2. Wang Chuan, Jin Chunlei, Zhang Jihui, Bao Qiyu, Liu Bo*, Huarong Tan*. Transcriptomic analysis of Thermoanaerobacter tengcongensis grown at different temperatures by RNA sequencing. Journal of Genetics and Genomics, 2015, DOI: 10.1016/j.jgg.2015.03.005. ( *, Corresponding author). 3. Liu Bo, Zhang Yuhong, Zhang Wei. RNA-Seq-based analysis of cold shock response in Thermoanaerobacter tengcongensis, a bacterium harboring a single cold shock protein encoding gene.PLoS One. 2014, 9(3):e93289. 4. NieChunming#, LiuBo#, ZhangYuhong, ZhaoGuofen, Fan Xiaohu, NingXiaoyan, ZhangWei. Production and secretion of Lactobacillus crispatus beta-galactosidase in Pichia pastoris. Protein Expression and Purification, 2013, 92, 88-92. (#, Co-first Author) 6.LiuBo, Wang Chuan, YangHaihua, TanHuarong. Establishment of a genetic transformation system and its application in Thermoanaerobacter tengcongensis. Journal of Genetics and Genomics, 2012, 39:561-570. 7. ZhangShuli#, LiuBo#, YangHaihua, TianYuqing, LiuGang, LiLei, TanHuarong. Characterization of EndoTT, a novel single-stranded DNA specific endonuclease from Thermoanaerobacter tengcongensis. Nucleic Acids Research, 2010, 38: 3709–3720. (#, Co-first author)
Chengliang Yan, Xinxin Xu, Xue Zhang, Yuwei Zhang, uhong Zhang, Zhifang Zhang,
Wei Zhang* and Bo Liu*. Decreased rhamnose metabolic flux improved production of target proteins and cell flocculation in Pichia pastoris. Front. Microbiol. 2018, 9: 1771. doi: 10.3389/fmicb.2018.01771.
Bo Liu, Yuwei Zhang, Xue Zhang, Chengliang Yan, Yuhong Zhang, Xinxin Xu, Wei Zhang. Discovery of a rhamnose utilization pathway and rhamnose-inducible promoters in Pichia pastoris. Scientific Reports, 2016, 6:27352. 2. Wang Chuan, Jin Chunlei, Zhang Jihui, Bao Qiyu, Liu Bo*, Huarong Tan*. Transcriptomic analysis of Thermoanaerobacter tengcongensis grown at different temperatures by RNA sequencing. Journal of Genetics and Genomics, 2015, DOI: 10.1016/j.jgg.2015.03.005. ( *, Corresponding author). 3. Liu Bo, Zhang Yuhong, Zhang Wei. RNA-Seq-based analysis of cold shock response in Thermoanaerobacter tengcongensis, a bacterium harboring a single cold shock protein encoding gene.PLoS One. 2014, 9(3):e93289. 4. NieChunming#, LiuBo#, ZhangYuhong, ZhaoGuofen, Fan Xiaohu, NingXiaoyan, ZhangWei. Production and secretion of Lactobacillus crispatus beta-galactosidase in Pichia pastoris. Protein Expression and Purification, 2013, 92, 88-92. (#, Co-first Author) 6.LiuBo, Wang Chuan, YangHaihua, TanHuarong. Establishment of a genetic transformation system and its application in Thermoanaerobacter tengcongensis. Journal of Genetics and Genomics, 2012, 39:561-570. 7. ZhangShuli#, LiuBo#, YangHaihua, TianYuqing, LiuGang, LiLei, TanHuarong. Characterization of EndoTT, a novel single-stranded DNA specific endonuclease from Thermoanaerobacter tengcongensis. Nucleic Acids Research, 2010, 38: 3709–3720. (#, Co-first author)