1994.04-1998.06 云南中医学院，理学学士（中药学）
1998.07-2000.10 昆明友谊制药厂 质量保证、质量控制 科长
2000.11-2001.09 中国科学院昆明植物研究所 科研人员
2001.09-2004.06 广西师范学院，理学硕士（有机化学）
2004.09-2005.08 昆明师范专科学校 讲师 兼职团支部书记
2005.09-2006.02 药明康德新药开发有限公司 有机合成 Synthesis Scientist
2006.03-2006.06 华东理工大学，制药工程与技术 专业课程学习
2006.08-2009.05 清华大学分析中心 代谢组学研究 博士（联培）
2009.10-2011.12 中科院植物研究所信号转导与代谢组学研究中心从事博士后研究，植物代谢组学方向
2011.11-2019.12 中国农业科学院生物技术研究所 助理研究员
2020年1月至今任中国农科院生物技术研究所副研究员
人才团队
韩莉妲博士、副研究员
研究中心
创新团队
课 题 组
招生方向
学习工作经历
主要研究领域与成果
主持中国农业科学院代谢组学专业公共实验室建设
主要从事代谢组学共性技术、方法研究
主持“农业生物代谢组学共性技术的建立和推广”“作物微量营养代谢组高效分析技术体系构建”等项目研究
2020年入选中国农业科学院首届“支撑英才”
农业生物技术平台中心常务副主任
发表SCI引用学术论文13篇，单篇最高120余次
获授权发明专利3项，实用新型专利1项
所负责平台中心屡次在获得科技部、财政部联合举办的“中央级高校和科研院所等单位重大科研基础设施和大型科研仪器开放共享评价考核”中名列前茅（名次8/373)，为多个科研团队和企业提供了研究方案、技术服务、机时共享、数据处理等多种形式的服务支撑，支撑合作团队在Nature Communications、Nature Plants、PNAS等高水平学术刊物发表研究论文20余篇。
中国医药生物技术协会 药物分析技术分会 委员会委员
中国仪器仪表学会科学仪器验证评价中心（生命科学站）专家委员会委员
主要论著
1.HAN Li-Da, CUI Jian-Guo, HUANG Chu-Sheng*, Bioactive Polyhydroxy Sterols and Their Sapogenins from Marine Organisms, Chinese Journal of Organic Chemistry, 2003,23(3)，305-311
2.Lida Han, Qionglin Liang, Yiming Wang, Ping Hu, Guoan Luo*, A new metabonomics method for simultaneous determination of EFAs and NEFAs in plasma using GC-MS and its application Chinese Chemical Letters, 2009,20,1103-1106
3.Lida Han, Qionglin Liang, Yiming Wang, Guoan Luo*, Serum EFAs and NEFAs Metabolic Profiling Analysis Child-bearing Age Women and Its Application to NTDs Preventive Nutrition Intervention Study, Chemical Journal of Chinese Universities, 2010,31，46-50
4.Li-Da Han, Jian-Fei Xia, Qiong-Lin Liang, Yong Wang, Yi-Ming Wang, Ping Hu, Ping Li, Guo-An Luo*, Plasma esterified and non-esterified fatty acids metabolic profiling using gas chromatography – mass spectrometry and its application in the study of diabetic mellitus and diabetic nephropathy, Analytica Chimica Acta, 2011,689,85–91
5.Xing Wan#, Lida Han#, Min Yang, Hong-Yang Zhang, Chun-Yi Zhang*, Ping Hu*, Simultaneous extraction and determination of mono-/polyglutamyl folates by high performance liquid chromatography-tandem mass spectrometry and its applications in starchy crops, Analytical and Bioanalytical Chemistry, 2019,411:2891–2904
6.Jin-Dan Zhang, Lida Han, Shijuan Yan and Chun-Ming Liu, The non-metabolizable glucose analog D-glucal inhibits aflatoxin biosynthesis and promotes kojic acid production in Aspergillus flavus BMC microbiology, 2014, 14:95，1471-2180
部分支撑论文：
1.Xiao Shi, Xuehui Sun, Zhiguo Zhang, Dan Feng, Qian Zhang, Lida Han, Jinxia Wu, and Tiegang Lu, GLUCAN SYNTHASE-LIKE 5 (GSL5) Plays an Essential Role in Male Fertility by Regulating Callose Metabolism During Microsporogenesis in Rice Plant ＆ Cell Physiology, 2015,56(3): 497–509
2.Yang Zhong, Xiaofeng Xue, Zhiqiang Liu, Yongshuo Ma, Kewu Zeng, Lida Han, Jingjing Qi, Dae-Kyun Ro, Søren Bak, Sanwen Huang, Yuan Zhou, and Yi Shang, Developmentally Regulated Glucosylation of Bitter Triterpenoid in Cucumber by the UDP-Glucosyltransferase UGT73AM3, Molecular Plant, 2017,10, 1000–1003
3.Lei Wang, Dongdong Kong, Qiang Lv, Guoqi Niu, Tingting Han, Xuanchao Zhao, Shulin Meng, Qian Cheng, Shouchun Guo, Jing Du, Zili Wu, Jinzheng Wang, Fang Bao, Yong Hu, Xiaojun Pan, Jinchan Xia, Dong Yuan, Lida Han, Tong Lian, Chunyi Zhang, Haiyang Wang, Xin-Jian He, and Yi-kun He, Tetrahydrofolate Modulates Floral Transition through Epigenetic Silencing, Plant Physiology, 2017, 174,1274–1284
4.Linan Xie, Liwen Zhang, Chen Wang, Xiaojing Wang, Ya-ming Xu, Hefen Yu, Ping Wu, Shenglan Li, Lida Han, A. A. Leslie Gunatilaka, Xiaoyi Wei, Min Lin, István Molnár, and Yuquan Xu, Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis, PNAS, 2018，vol.115，no.22，E4980–E4989
5. Jing Bai, Peng Zhang, Guanhu Bao, Jin-Gang Gu, Lida Han1, Li-Wen Zhang, Yuquan Xu, Imaging mass spectrometry-guided fast identification of antifungal secondary metabolites from Penicillium polonicum, Applied Microbiology and Biotechnology, 2018,102:8493–8500
6. Dawei Li, Yongshuo Ma, Yuan Zhou, Junbo Gou, Yang Zhong, Lingling Zhao, Lida Han, Sergey Ovchinnikov, Ling Ma, Sanwen Huang, Per Greisen & Yi Shang, A structural and data-driven approach to engineering a plant cytochrome P450 enzyme, Science China, 2019,62(7):873-882
7. Lihua Zhang, Guoqing Lu, Xinzheng Huang, Huiming Guo, Xiaofeng Su, Lida Han, Yongjun Zhang, Zhi Qi, Yutao Xiao and Hongmei Cheng, Overexpression of the caryophyllene synthase gene GhTPS1 in cotton negatively affects multiple pests while attracts parasitoids. Pest Management Science, 2019,doi: 10.1002/ps.5695.
8. Mehmood Shahid, Tong Lian, Xing Wan, Ling Jiang, Lida Han, Chunyi Zhang, Qiuju Liang, Folate monoglumate in cereal grains: Evaluation of extraction techniques and determination by LC-MS/MS Journal of Food Composition and Analysis, 2020, (91), 103510
9. Lihua Zhang, Guoqing Lu, Xinzheng Huang Huiming Guo, Xiaofeng Su, Lida Han Yongjun Zhan, Zhi Qi, Yutao Xiao, Hongmei Cheng, Overexpression of the caryophyllene synthase gene GhTPS1 in cotton negatively affects multiple pests while attracting parasitoids, PEST MANAGEMENT SCIENCE, 2020 May;76(5):1722-1730.
10. Tianbao Zhang, Zhen Li, Xiaxia Song, Lida Han, Liming Wang, Jianping Wang, Yan Long, Xinwu Pei, Identification and characterization of microRNAs in the developing seed of linseed flax (Linum usitatissimum L.) International Journal of Molecular Sciences , 2020, 21(8), 2708
主要专利
韩莉妲，张春义，万幸，杨敏，玉米籽粒中叶酸的提取和定量方法 国家发明专利，ZL 2018 1 1041330.X
韩莉妲，万幸，杨敏，龚丹丹, 一种无氧操作箱，实用新型专利, ZL 2018 2 0675498.5
刘春明, 张晋丹, 晏石娟, 韩莉妲，利用D-glucal抑制黄曲霉毒素产生的方法 国家发明专利, ZL 2010 1 0521546.3
主要从事代谢组学共性技术、方法研究
主持“农业生物代谢组学共性技术的建立和推广”“作物微量营养代谢组高效分析技术体系构建”等项目研究
2020年入选中国农业科学院首届“支撑英才”
农业生物技术平台中心常务副主任
发表SCI引用学术论文13篇，单篇最高120余次
获授权发明专利3项，实用新型专利1项
所负责平台中心屡次在获得科技部、财政部联合举办的“中央级高校和科研院所等单位重大科研基础设施和大型科研仪器开放共享评价考核”中名列前茅（名次8/373)，为多个科研团队和企业提供了研究方案、技术服务、机时共享、数据处理等多种形式的服务支撑，支撑合作团队在Nature Communications、Nature Plants、PNAS等高水平学术刊物发表研究论文20余篇。
中国医药生物技术协会 药物分析技术分会 委员会委员
中国仪器仪表学会科学仪器验证评价中心（生命科学站）专家委员会委员
主要论著
1.HAN Li-Da, CUI Jian-Guo, HUANG Chu-Sheng*, Bioactive Polyhydroxy Sterols and Their Sapogenins from Marine Organisms, Chinese Journal of Organic Chemistry, 2003,23(3)，305-311
2.Lida Han, Qionglin Liang, Yiming Wang, Ping Hu, Guoan Luo*, A new metabonomics method for simultaneous determination of EFAs and NEFAs in plasma using GC-MS and its application Chinese Chemical Letters, 2009,20,1103-1106
3.Lida Han, Qionglin Liang, Yiming Wang, Guoan Luo*, Serum EFAs and NEFAs Metabolic Profiling Analysis Child-bearing Age Women and Its Application to NTDs Preventive Nutrition Intervention Study, Chemical Journal of Chinese Universities, 2010,31，46-50
4.Li-Da Han, Jian-Fei Xia, Qiong-Lin Liang, Yong Wang, Yi-Ming Wang, Ping Hu, Ping Li, Guo-An Luo*, Plasma esterified and non-esterified fatty acids metabolic profiling using gas chromatography – mass spectrometry and its application in the study of diabetic mellitus and diabetic nephropathy, Analytica Chimica Acta, 2011,689,85–91
5.Xing Wan#, Lida Han#, Min Yang, Hong-Yang Zhang, Chun-Yi Zhang*, Ping Hu*, Simultaneous extraction and determination of mono-/polyglutamyl folates by high performance liquid chromatography-tandem mass spectrometry and its applications in starchy crops, Analytical and Bioanalytical Chemistry, 2019,411:2891–2904
6.Jin-Dan Zhang, Lida Han, Shijuan Yan and Chun-Ming Liu, The non-metabolizable glucose analog D-glucal inhibits aflatoxin biosynthesis and promotes kojic acid production in Aspergillus flavus BMC microbiology, 2014, 14:95，1471-2180
部分支撑论文：
1.Xiao Shi, Xuehui Sun, Zhiguo Zhang, Dan Feng, Qian Zhang, Lida Han, Jinxia Wu, and Tiegang Lu, GLUCAN SYNTHASE-LIKE 5 (GSL5) Plays an Essential Role in Male Fertility by Regulating Callose Metabolism During Microsporogenesis in Rice Plant ＆ Cell Physiology, 2015,56(3): 497–509
2.Yang Zhong, Xiaofeng Xue, Zhiqiang Liu, Yongshuo Ma, Kewu Zeng, Lida Han, Jingjing Qi, Dae-Kyun Ro, Søren Bak, Sanwen Huang, Yuan Zhou, and Yi Shang, Developmentally Regulated Glucosylation of Bitter Triterpenoid in Cucumber by the UDP-Glucosyltransferase UGT73AM3, Molecular Plant, 2017,10, 1000–1003
3.Lei Wang, Dongdong Kong, Qiang Lv, Guoqi Niu, Tingting Han, Xuanchao Zhao, Shulin Meng, Qian Cheng, Shouchun Guo, Jing Du, Zili Wu, Jinzheng Wang, Fang Bao, Yong Hu, Xiaojun Pan, Jinchan Xia, Dong Yuan, Lida Han, Tong Lian, Chunyi Zhang, Haiyang Wang, Xin-Jian He, and Yi-kun He, Tetrahydrofolate Modulates Floral Transition through Epigenetic Silencing, Plant Physiology, 2017, 174,1274–1284
4.Linan Xie, Liwen Zhang, Chen Wang, Xiaojing Wang, Ya-ming Xu, Hefen Yu, Ping Wu, Shenglan Li, Lida Han, A. A. Leslie Gunatilaka, Xiaoyi Wei, Min Lin, István Molnár, and Yuquan Xu, Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis, PNAS, 2018，vol.115，no.22，E4980–E4989
5. Jing Bai, Peng Zhang, Guanhu Bao, Jin-Gang Gu, Lida Han1, Li-Wen Zhang, Yuquan Xu, Imaging mass spectrometry-guided fast identification of antifungal secondary metabolites from Penicillium polonicum, Applied Microbiology and Biotechnology, 2018,102:8493–8500
6. Dawei Li, Yongshuo Ma, Yuan Zhou, Junbo Gou, Yang Zhong, Lingling Zhao, Lida Han, Sergey Ovchinnikov, Ling Ma, Sanwen Huang, Per Greisen & Yi Shang, A structural and data-driven approach to engineering a plant cytochrome P450 enzyme, Science China, 2019,62(7):873-882
7. Lihua Zhang, Guoqing Lu, Xinzheng Huang, Huiming Guo, Xiaofeng Su, Lida Han, Yongjun Zhang, Zhi Qi, Yutao Xiao and Hongmei Cheng, Overexpression of the caryophyllene synthase gene GhTPS1 in cotton negatively affects multiple pests while attracts parasitoids. Pest Management Science, 2019,doi: 10.1002/ps.5695.
8. Mehmood Shahid, Tong Lian, Xing Wan, Ling Jiang, Lida Han, Chunyi Zhang, Qiuju Liang, Folate monoglumate in cereal grains: Evaluation of extraction techniques and determination by LC-MS/MS Journal of Food Composition and Analysis, 2020, (91), 103510
9. Lihua Zhang, Guoqing Lu, Xinzheng Huang Huiming Guo, Xiaofeng Su, Lida Han Yongjun Zhan, Zhi Qi, Yutao Xiao, Hongmei Cheng, Overexpression of the caryophyllene synthase gene GhTPS1 in cotton negatively affects multiple pests while attracting parasitoids, PEST MANAGEMENT SCIENCE, 2020 May;76(5):1722-1730.
10. Tianbao Zhang, Zhen Li, Xiaxia Song, Lida Han, Liming Wang, Jianping Wang, Yan Long, Xinwu Pei, Identification and characterization of microRNAs in the developing seed of linseed flax (Linum usitatissimum L.) International Journal of Molecular Sciences , 2020, 21(8), 2708
主要专利
韩莉妲，张春义，万幸，杨敏，玉米籽粒中叶酸的提取和定量方法 国家发明专利，ZL 2018 1 1041330.X
韩莉妲，万幸，杨敏，龚丹丹, 一种无氧操作箱，实用新型专利, ZL 2018 2 0675498.5
刘春明, 张晋丹, 晏石娟, 韩莉妲，利用D-glucal抑制黄曲霉毒素产生的方法 国家发明专利, ZL 2010 1 0521546.3